50. ceremonia wręczenia nagród Grammy – nominacje do nagród za dokonania muzyczne zrealizowane od 1 października 2006 roku do 30 września 2007 roku ogłoszone zostały 6 grudnia 2007 roku, a uroczyste przyznanie nagród odbyło się 10 lutego 2008 roku w Staples Center, Los Angeles. Na poprzedzającej ceremonię wręczenia Nagród Grammy gali MusiCares, Aretha Franklin została wyróżniona jako Person of the Year za całościowy wkład w historię muzyki.

Zwyciężczynią wieczoru została Amy Winehouse, która otrzymała z sześciu nominacji pięć nagród. Winehouse poddała się na krótko przed ceremonią leczeniu odwykowemu i początkowo nie otrzymała wizy do USA. Gdy decyzja została zmieniona było już za późno na zorganizowanie wyjazdu i występy Winehouse zostały transmitowane z Londynu.

• Chris Brown
• Cher
• Fergie
• Cuba Gooding Jr.
• Juanes
• Tom Hanks
• Quincy Jones
• Cyndi Lauper
• John Legend
• Bette Midler
• Prince
• Keely Smith
• Ringo Starr
• Usher
• Stevie Wonder

• Alicia Keys
• Amy Winehouse (transmisja z Londynu)
• Andrea Bocelli
• Aretha Franklin
• Beyoncé Knowles
• Carrie Underwood
• Fergie z John Legend
• Foo Fighters
• Herbie Hancock
• Jerry Lee Lewis
• John Mayer
• John Paul Jones
• Kanye West z Daft Punk
• Kid Rock
• Lang Lang
• Rihanna
• The Time

• "Irreaplaceable" Beyoncé Knowles (producenci: Jim Caruana, Jason Goldstein & Geoff Rice)
• "The Pretender" Foo Fighters (producenci: Adrian Bushby & Rich Costey)
• "What Goes Around...Comes Around" Justin Timberlake (producenci: Jimmy Douglass & Timbaland)
• "Rehab" Amy Winehouse (producent: Tom Elmhirst)

• "Echoes, Silence, Patience & Grace" Foo Fighters
• "These Days" Vince Gill
• "River: The Joni Letters" Herbie Hancock
• "Graduation" Kanye West
• " Back To Black" Amy Winehouse

• "Before He Cheats" Carrie Underwood
• "Hey There Delilah" Plain White T’s
• "Like A Star" Corinne Bailey Rae
• "Rehab" Amy Winehouse
• "Umbrella" Rihanna z Jay-Z

• Feist
• Ledisi
• Paramore
• Taylor Swift
• Amy Winehouse

• "Candyman" Christina Aguilera
• "1234" Feist
• "Big Girls Don't Cry" Fergie
• "Say It Right" Nelly Furtado
• "Rehab" Amy Winehouse

• "Everything" Michael Bublé
• "Belief" John Mayer
• "Dance Tonight" Paul McCartney
• "Amazing" Seal
• "What Goes Around...Comes Around" Justin Timberlake

• "(You Want To) Make A Memory" Bon Jovi
• "Home" Daughtry
• "Makes Me Wonder" Maroon 5
• "Hey There Delilah" Plain White T’s
• "Window In The Skies" U2

• "Steppin' Out" Tony Bennett & Christina Aguilera
• "Beautiful Liar" Beyoncé & Shakira
• "Gone Gone Gone (Done Moved On)" Robert Plant & Alison Krauss
• "The Sweet Escape" Gwen Stefani & Akon
• "Give It To Me" Timbaland z Nelly Furtado & Justin Timberlake

• "Off The Grid" Beastie Boys
• "Paris Sunrise #7" Ben Harper & The Innocent Criminals
• "Over The Rainbow" Dave Koz
• "One Week Last Summer" Joni Mitchell
• "Simple Pleasures" Spyro Gyra

• "The Mix-Up" Beastie Boys
• "Italia" Chris Botti
• "At The Movies" Dave Koz
• "Good To Go-Go" Spyro Gyra
• "Roundtrip" Kirk Whalum

• "Lost Highway" Bon Jovi
• "The Reminder" Feist
• "It Won't Be Soon Before Long" Maroon 5
• "Memory Almost Full" Paul McCartney
• "Back To Black" Amy Winehouse

• "Do It Again" The Chemical Brothers
• "D.A.N.C.E." Justice
• "Love Today" Mika
• "Don’t Stop The Music" Rihanna
• "LoveStoned/I Think She Knows" Justin Timberlake

• "We Are The Night" The Chemical Brothers
• " T" Justice
• "Sound Of Silver" LCD Soundsystem
• "We Are Pilots" Shiny Toy Guns
• "Elements Of Life" Tiësto

• "Call Me Irresponsible" Michael Bublé
• "Cool Yule" Bette Midler
• "Trav'lin' Light" Queen Latifah
• "Live In Concert 2006" Barbra Streisand
• "James Taylor At Christmas" James Taylor

• "Timebomb" Beck
• "Only Mama Knows" Paul McCartney
• "Our Country" John Mellencamp
• "Radio Nowhere" Bruce Springsteen
• "Come On" Lucinda Williams

• "It's Not Over" Daughtry
• "Working Class Hero" Green Day
• "If Everyone Cared" Nickelback
• "Instant Karma" U2
• "Icky Thump" The White Stripes

• "Sweet Sacrifice" Evanescence
• "The Pretender" Foo Fighters
• "I Don’t Wanna Stop" Ozzy Osbourne
• "Sick, Sick, Sick" Queens of the Stone Age
• "The Pot" Tool

• "Nothing Left" As I Lay Dying
• "Never Ending Hill" King Diamond
• "Aesthetics Of Hate" Machine Head
• "Redemption" Shadows Fall
• "Final Six" Slayer

• "The Ecstasy Of Gold" Metallica
• "Malignant Narcissism" Rush
• "Always With Me, Always With You" Joe Satriani
• "Once Upon A Time In The West" Bruce Springsteen
• "The Attitude Song" Steve Vai

• "Come On" Lucinda Williams
• "Icky Thump" Jack White
• "It's Not Over" Daughtry
• "The Pretender" Foo Fighters
• "Radio Nowhere" Bruce Springsteen

• "Daughtry" Daughtry
• "Revival" John Fogerty
• "Echoes, Silence, Patience & Grace" Foo Fighters
• "Magic" Bruce Springsteen
• "Sky Blue Sky" Wilco

• "Alright, Still..." Lily Allen
• "Neon Bible" Arcade Fire
• "Volta" Bjork
• "Wincing The Night Away" The Shins
• "Icky Thump" The White Stripes

• "Just Fine" Mary J. Blige
• "When I See You" Fantasia
• "No One" Alicia Keys
• "If I Have My Way" Chrisette Michele
• "Hate On Me" Jill Scott

• "Woman" Raheem DeVaughn
• "B.U.D.D.Y." Musiq Soulchild
• "Because Of You" Ne-Yo
• "Future Baby Mama" Prince
• "Please Don't Go" Tank

• "Same Girl" R. Kelly z Usher
• "Disrespectful" Chaka Khan z Mary J. Blige
• "Hate That I Love You" Rihanna z Ne-Yo
• "Baby" Angie Stone z Betty Wright
• "Bartender" T-Pain z Akon

• "Walk A Mile In My Shoes" Otis Clay
• "All Night Long" Randy Crawford & Joe Sample
• "In My Songs" Gerald Levert
• "I Apologize" Ann Nesby
• "I Am Your Man" Ryan Shaw

• "Make A Baby" Vikter Duplaix
• "That's The Way Of The World" Dwele
• "Daydreamin" Lupe Fiasco z Jill Scott
• "Fantasy" Me’shell Ndegeocello
• "Dream" Alice Smith

• "Beautiful Flower" India.Arie
• "Hate That I Love You" Rihanna Ne-Yo
• "No One" Alicia Keys
• "Teachme" Musiq Soulchild
• "When I See U" Fantasia

• "Funk This" Chaka Khan
• "Lost & Found" Ledisi
• "Luvanmusiq" Musiq Soulchild
• "The Real Thing" Jill Scott
• "Sex, Love & Pain" Tank

• "Konvicted" Akon
• "Just Like You" Keyshia Cole
• "Fantasia" Fantasia
• "East Side Story" Emily King
• "Because Of You" Ne-Yo

• "The People" Common
• "I Get Money" 50 Cent
• "Show Me What You Got" Jay-Z
• "Big Things Poppin' (Do It)" T.I.
• "Stronger" Kanye West

• "Southside" Common z Kanye West
• "Make It Rain" Fat Joe z Lil Wayne
• "Party Like A Rockstar" Shop Boyz
• "Int'l Players Anthem (I Choose You)" UGK z OutKast
• "Better Than I've Ever Been" Kanye West, Nas & KRS-One

• "I Wanna Love You" Akon z Snoop Dogg
• "Kiss, Kiss" Chris Brown & T-Pain
• "Let It Go" Keyshia Cole z Missy Elliott & Lil’ Kim
• "Umbrella" Rihanna z Jay-Z
• "Good Life" Kanye West z T-Pain

• "Ayo Technology" 50 Cent z Justin Timberlake & Timbaland
• "Big Things Poppin' (Do It)" T.I.
• "Can't Tell Me Nothing" Kanye West
• "Crank That (Soulja Boy)" Soulja Boy Tell'Em
• "Good Life" Kanye West z T-Pain

• "Finding Forever" Common
• "Kingdom Come" Jay-Z
• "Hip Hop Is Dead" Nas
• "T.I. vs T.I.P." T.I.
• "Graduation" Kanye West

• "Before He Cheats" Carrie Underwood

• "Stupid Boy" Keith Urban

• "How Long (J. D. Souther song)" Eagles

• "Lost Highway" Willie Nelson & Ray Price

• '"Throttleneck" Brad Paisley

• "Before He Cheats" Carrie Underwood

• "These Days" Vince Gill

• "The Bluegrass Diaries" Jim Lauderdale

• "Crestone" Paul Winter Consort

• "River: The Joni Letters" Herbie Hancock

• "Avant Gershwin" Patti Austin

• "Anagram" Michael Brecker

• "Pilgrimage" Michael Brecker

• "A Tale of God's Will (A Requiem for Katrina)" Terence Blanchard

• "Funk Tango" Paquito D' Rivera

• "Last of the Great Mississippi Delta Bluesmen: Live In Dallas" Henry Townsend, Joe Willie "Pinetop" Perkins, Robert Lockwood, Jr. & David Honeyboy Edwards

• "The Road to Escondido" JJ Cale & Eric Clapton