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Mutasjon E484Q

E484Q er en mutasjon av piggproteinetSARS-CoV-2, viruset som forårsaker covid-19. Navnet på mutasjonen, E484Q, viser til en endring hvorved glutaminsyre (E) er utskiftet med glutamin (Q) i posisjon 484.[1]

India opplevde våren 2021 under koronaviruspandemiens andre år en voldsom økning av covid-19, og man fant at den hadde sammenheng med en «dobbel mutant». Denne dobbelmutanten har fått navnet Lineage B.1.617. E484Q er nøkkelmutasjonen, ved det at den forøker ACE2-reseptorens bindeevne og reduserer eksisterende antistoffers evne fra å knytte an til det slik muterte, og dermed annerledes foldede, piggproteinet.[2]

Referanser

[rediger | rediger kilde]
  1. ^ «"What Mutations of SARS-CoV-2 are Causing Concern?"]». News Medical Lifesciences. 15. januar 2021. Besøkt 16. januar 2021. 
  2. ^ «Coronavirus | Indian 'double mutant' strain named B.1.617». The Hindu (engelsk). 8. april 2021. 
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Mutasjon E484Q
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