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ジアミンオキシダーゼ

ジアミンオキシダーゼ
識別子
EC番号 1.4.3.22
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ジアミンオキシダーゼ(diamine oxidase)は、アルギニンプロリンヒスチジントリプトファン代謝酵素の一つで、次の化学反応触媒する酸化還元酵素である。

ヒスタミン + H2O + O2 (イミダゾール-4-イル)アセトアルデヒド + NH3 + H2O2

反応式の通り、この酵素の基質ヒスタミンH2OO2、生成物は(イミダゾール-4-イル)アセトアルデヒドとNH3H2O2である。

組織名はhistamine:oxygen oxidoreductase (deaminating)で、別名にamine oxidase (ambiguous); amine oxidase (copper-containing) (ambiguous); CAO (ambiguous); Cu-containing amine oxidase (ambiguous); copper amine oxidase (ambiguous); diamine oxidase (ambiguous); diamino oxhydrase (ambiguous); histaminase; histamine deaminase (incorrect); semicarbazide-sensitive amine oxidase (incorrect); SSAO (incorrect)がある。

参考文献

[編集]
  • Zeller, E.A. Diamine oxidases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds), The Enzymes, 2nd edn, vol. 8, Academic Press, New York, 1963, pp. 313-335.
  • Crabbe, M.J., Waight, R.D., Bardsley, W.G., Barker, R.W., Kelly, I.D. and Knowles, P.F. (1976). “Human placental diamine oxidase. Improved purification and characterization of a copper- and manganese-containing amine oxidase with novel substrate specificity.”. Biochem. J. 155: 679-687. PMID 182134. 
  • Chassande, O., Renard, S., Barbry, P. and Lazdunski, M. (1994). “The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter.”. J. Biol. Chem. 269: 14484-14489. PMID 8182053. 
  • Houen, G. (1999). “Mammalian Cu-containing amine oxidases (CAOs): new methods of analysis, structural relationships, and possible functions.”. APMIS Suppl. 96: 1-46. PMID 10668504. 
  • Elmore, B.O., Bollinger, J.A. and Dooley, D.M. (2002). “Human kidney diamine oxidase: heterologous expression, purification, and characterization.”. J. Biol. Inorg. Chem. 7: 565-579. PMID 12072962. 
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ジアミンオキシダーゼ
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