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Sulesomab

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Sulesomab
Caratteristiche generali
Numero CAS167747-19-5
Codice ATCV09HA04
DrugBankDBDB13976
Indicazioni di sicurezza

Il 99mTc-sulesomab è un anticorpo monoclonale di topo legato chimicamente ad un radionuclide il tecnezio-99m, il cui nome commerciale è LeukoScan.[1]

Esso è approvato per la diagnostica per imaging delle infezioni e dell'infiammazione in corso di osteomielite;[2] è anche studiato per altre indicazioni come la diagnostica dei tessuti molli.[3]

L'anticorpo agisce legandosi al recettore delle cellule granulocitiche, la glicoproteina NCA-90.[4]

  1. ^ (EN) whqlibdoc.who.int (PDF) (archiviato dall'url originale il 4 giugno 2011).
  2. ^ (EN) European Medicines Agency, su ema.europa.eu (archiviato dall'url originale il 3 luglio 2011).
  3. ^ Quigley AM, Gnanasegaran G, Buscombe JR, Hilson AJ, Technetium-99m-labelled sulesomab (LeukoScan) in the evaluation of soft tissue infections, in Med Princ Pract, vol. 17, n. 6, 2008, pp. 447–52, DOI:10.1159/000151565, PMID 18836272.
  4. ^ Marie Audette, Franz Buchegger, Magali Schreyer e Jean-Pierre Mach, Monoclonal antibody against carcinoembryonic antigen (CEA) identifies two new forms of crossreacting antigens of molecular weight 90,000 and 160,000 in normal granulocytes, in Molecular Immunology, vol. 24, n. 11, novembre 1987, pp. 1177-1186, DOI:10.1016/0161-5890(87)90164-7, ISSN 0161-5890 (WC · ACNP).

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Sulesomab
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