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Alprostandil.
Alprostandil je lijek koji po kemijskoj strukturi spada u skupinu prostaglandina.
Prostaglandini su važne vazoaktivni derivati arahidonske kiseline koji pokazuju vazomotoričko, metaboličko i stanično djelovanje na plućnu i sistemsku cirkulaciju. E serija prostaglandina u koju spada i alprostandil izazivaju vazodilataciju sistemske i koronarne cirkulacije. Alprostandil blokira zatvaranje ductusa arteriosusa te se stoga koristi za palijativno liječenje, u svrhu održavanja prohodnosti ductus arteriosusa, do definitivnog kirurškog zbrinjavanja kongenitalne srčane mane novorođenčeta. Primjenjuje se u obliku infuzije samo u zdravstvenim ustanovama s mogućnošću primjene intenzivne pedijatrijske njege.
Češće nuspojave su apneja, crvenilo lica (rjeđe kod intravenske primjene) i bradikardija. U rijetkim slučajevima mogu se pojaviti epileptični napadi, hipotenzija, tahikardija i proljev.
| Lijekovi za liječenje bolesti kardiovaskularnog sustava (C) |
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| | Srčani glikozidi | Digitoksin • Gitoksin • Lanatozidi • Deslanozid • Digoksin • Metildigoksin • K-strofantin • Uabain • Cimarin • Konvalotoksin • Scilareni • Oleandrin • Viteksin | | | Antiaritmici | | | | Srčani stimulatori | | | | Vazodilatatori | Gliceriltrinitrat • Izosorbid mononitrat • Izosorbid dinitrat • Pentaeritritil tetranitrat • Amil-nitrat • Telitramin • Tolnitrat • Propatilnitrat | | | Ostali pripravci s učinkom na srce | | | | Antihipertenzivi | | | | Diuretici | | | | Periferni vazodilatatori | Pentoksifilin • Dihidroergotoksin • Naftidrofuril | | | Vazoprotektivi | | | | Beta blokatori | Alprenolol • Oksprenolol • Pindolol • Propranolol • Timolol • Sotalol • Nadolol • Mepindolol • Karteolol • Tertatolol • Bopindolol • Bupranolol • Penbutolol • Kloranolol • Praktolol • Metoprolol • Atenolol • Acebutolol • Betaksolol • Bevantolol • Bisoprolol • Celiprolol • Esmolol • Epanolol • S-atenolol • Nebivolol • Labetalol • Karvedilol | | | Blokatori kalcijevih kanala | Nifedipin • Amlodipin • Lacidipin • Nikardipin • Nimodipin • Nitrendipin • Felodipin • Izradipin • Nisoldipin • Nilvadipin • Manidipin • Barnidipin • Lerkanidipin • Verapamil • Galopamil • Bepridil • Fendilin • Diltiazem • Mibefradil | | | ACE inhibitori | | | | Antagonisti angiotenzina II | Losartan • Valsartan • Irbesartan • Kandesartan • Eprosartan • Telmisartan • Olmesartan medoksomil | | | Hipolipemici | Simvastatin • Lovastatin • Pravastatin • Fluvastatin • Atorvastatin • Cerivastatin • Rozuvastatin • Gemfibrozil • Klofibrat • Bezafibrat • Fenofibrat • Simfibrat • Ronifibrat • Ciprofibrat • Etofibrat • Klofibrid • Kolestiramin • Kolestipol • Kolekstran • Kolesevelam • Niceritrol • Nikotinska kiselina • Nikofuranoza • Aluminijev nikotinat • Nikotinil alkohol • Acipimoks • Probukol • Tiadenol • Benfluoreks • Meglutol • Omega-3-nezasićene masne kiseline • Magnezijev piridoksal 5-fosfat glutamat • Polikozanol • Ezetimib |
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