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Dosage radio-immunologique

Formule des réactions de dosage radio-immunologique (RIA)

En médecine nucléaire, le dosage radio-immunologique, également appelé radio-immunologie, est un test immunologique utilisant l'analyse radiochimique in vitro de composés radioactifs associés à des antigènes.

Elle sert à doser de manière très précise des substances biologiques tels que les anticorps, les hormones, les enzymes, ou les stéroïdes. Elle a été mise au point dans les années 1950 par les Américains Solomon Berson et Rosalyn Yalow[1],[2]. De nos jours, la méthode immuno-enzymatique ELISA a largement supplanté la radio-immunologie.

Notes et références

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  1. (en) Berson, Solomon A., et al. "Insulin-I 131 metabolism in human subjects: demonstration of insulin binding globulin in the circulation of insulin treated subjects." The Journal of clinical investigation 35.2 (1956): 170-190.
  2. (en) Berson, Solomon A., and Rosalyn S. Yalow. "Quantitative aspects of the reaction between insulin and insulin-binding antibody." The Journal of clinical investigation 38.11 (1959): 1996-2016.
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Dosage radio-immunologique
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