NRXN3
نورِکسین-۳-آلفا (انگلیسی: Neurexin-3-alpha) یک پروتئین است که در انسان توسط ژن «NRXN3» کُدگذاری میشود.[۴][۵][۶] این ژن به همراه ژن NRXN1 از بزرگترین ژنهای انسان محسوب میشوند.
تصور بر آن است که این پروتئین در انعطافپذیری سیناپسی (Synaptic plasticity) نقش داشته باشد و پُلیمورفیسم در این ژن را، به استعداد ژنتیکی افراد در اعتیاد به الکل یا سوءمصرف مواد[۷][۸][۹] و همچنین چاقی[۱۰] نسبت دادهاند.
منابع
[ویرایش]- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000066392 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Rowen L, Young J, Birditt B, Kaur A, Madan A, Philipps DL, Qin S, Minx P, Wilson RK, Hood L, Graveley BR (Apr 2002). "Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity". Genomics. 79 (4): 587–97. doi:10.1006/geno.2002.6734. PMID 11944992.
- ↑ Occhi G, Rampazzo A, Beffagna G, Antonio Danieli G (Oct 2002). "Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3)". Biochem Biophys Res Commun. 298 (1): 151–5. doi:10.1016/S0006-291X(02)02403-8. PMID 12379233.
- ↑ "Entrez Gene: NRXN3 neurexin 3".
- ↑ Lachman HM, Fann CS, Bartzis M, Evgrafov OV, Rosenthal RN, Nunes EV, Miner C, Santana M, Gaffney J, Riddick A, Hsu CL, Knowles JA (June 2007). "Genomewide suggestive linkage of opioid dependence to chromosome 14q". Human Molecular Genetics. 16 (11): 1327–34. doi:10.1093/hmg/ddm081. PMID 17409192.
- ↑ Hishimoto A, Liu QR, Drgon T, Pletnikova O, Walther D, Zhu XG, Troncoso JC, Uhl GR (December 2007). "Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms". Human Molecular Genetics. 16 (23): 2880–91. doi:10.1093/hmg/ddm247. PMID 17804423.
- ↑ Kelai S, Maussion G, Noble F, Boni C, Ramoz N, Moalic JM, Peuchmaur M, Gorwood P, Simonneau M (May 2008). "Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction". NeuroReport. 19 (7): 751–5. doi:10.1097/WNR.0b013e3282fda231. PMC 4710739. PMID 18418251.
- ↑ Heard-Costa NL, Zillikens MC, Monda KL, Johansson A, Harris TB, Fu M, Haritunians T, Feitosa MF, Aspelund T, Eiriksdottir G, Garcia M, Launer LJ, Smith AV, Mitchell BD, McArdle PF, Shuldiner AR, Bielinski SJ, Boerwinkle E, Brancati F, Demerath EW, Pankow JS, Arnold AM, Chen YD, Glazer NL, McKnight B, Psaty BM, Rotter JI, Amin N, Campbell H, Gyllensten U, Pattaro C, Pramstaller PP, Rudan I, Struchalin M, Vitart V, Gao X, Kraja A, Province MA, Zhang Q, Atwood LD, Dupuis J, Hirschhorn JN, Jaquish CE, O'Donnell CJ, Vasan RS, White CC, Aulchenko YS, Estrada K, Hofman A, Rivadeneira F, Uitterlinden AG, Witteman JC, Oostra BA, Kaplan RC, Gudnason V, O'Connell JR, Borecki IB, van Duijn CM, Cupples LA, Fox CS, North KE (June 2009). Dermitzakis ET (ed.). "NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium". PLoS Genetics. 5 (6): e1000539. doi:10.1371/journal.pgen.1000539. PMC 2695005. PMID 19557197.
- مشارکتکنندگان ویکیپدیا. «NRXN3». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۲۰ مه ۲۰۱۸.
بیشتر بخوانید
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