پوزانیکلین

پوزانیکلین
شناسه‌ها
	نام آیوپاک 2-Methyl-3-{[(2S)-pyrrolidin-2-yl]methoxy}pyridine;
شمارهٔ سی‌ای‌اس	161417-03-4 ;
پاب‌کم CID	178052;
کم‌اسپایدر	155000 ;
UNII	CL2002R563;
CompTox Dashboard (EPA)	DTXSID20167149 ;
داده‌های فیزیکی و شیمیایی
فرمول شیمیایی	C11H16N2O
جرم مولی	۱۹۲٫۲۶۲ g·mol−1
مدل سه بعدی (جی‌مول)	Interactive image;
	SMILES CC1=C(C=CC=N1)OC[C@@H]2CCCN2;
	InChI InChI=1S/C11H16N2O/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10/h3,5-6,10,13H,2,4,7-8H2,1H3/t10-/m0/s1 ; Key:YRVIKLBSVVNSHF-JTQLQIEISA-N ;
	(این چیست؟) (صحت‌سنجی)

پوزانیکلین (انگلیسی: Pozanicline)^[۱] دارویی است دارای اثرات نوتروپیک و محافظت کننده عصبی است.^[۲]^[۳]^[۴] پژوهش‌های جانوری نشان داد که برای درمان ADHD سودمند است.^[۵]

منابع

↑ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 62" (PDF). World Health Organization. p. 257. Archived (PDF) from the original on 18 May 2016. Retrieved 3 January 2017.
↑ Lin NH, Gunn DE, Ryther KB, Garvey DS, Donnelly-Roberts DL, Decker MW, et al. (January 1997). "Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties". Journal of Medicinal Chemistry. 40 (3): 385–90. doi:10.1021/jm960233u. PMID 9022806.
↑ Sullivan JP, Donnelly-Roberts D, Briggs CA, Anderson DJ, Gopalakrishnan M, Xue IC, et al. (October 1997). "ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 235–46. PMID 9336329.
↑ Decker MW, Bannon AW, Curzon P, Gunther KL, Brioni JD, Holladay MW, et al. (October 1997). "ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 247–58. PMID 9336330.
↑ Prendergast MA, Jackson WJ, Terry AV, Decker MW, Arneric SP, Buccafusco JJ (March 1998). "Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys". Psychopharmacology. 136 (1): 50–8. doi:10.1007/s002130050538. PMID 9537682. S2CID 20080069.

مشارکت‌کنندگان ویکی‌پدیا. «Pozanicline». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۶ آوریل ۲۰۲۴.

پیوند به بیرون

رده‌ها

[INN-1] "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 62" (PDF). World Health Organization. p. 257. Archived (PDF) from the original on 18 May 2016. Retrieved 3 January 2017.

[2] Lin NH, Gunn DE, Ryther KB, Garvey DS, Donnelly-Roberts DL, Decker MW, et al. (January 1997). "Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties". Journal of Medicinal Chemistry. 40 (3): 385–90. doi:10.1021/jm960233u. PMID 9022806.

[3] Sullivan JP, Donnelly-Roberts D, Briggs CA, Anderson DJ, Gopalakrishnan M, Xue IC, et al. (October 1997). "ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 235–46. PMID 9336329.

[4] Decker MW, Bannon AW, Curzon P, Gunther KL, Brioni JD, Holladay MW, et al. (October 1997). "ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 247–58. PMID 9336330.

[5] Prendergast MA, Jackson WJ, Terry AV, Decker MW, Arneric SP, Buccafusco JJ (March 1998). "Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys". Psychopharmacology. 136 (1): 50–8. doi:10.1007/s002130050538. PMID 9537682. S2CID 20080069.

[۱]

[۲]

[۳]

[۴]

[۵]

پوزانیکلین

منابع

پیوند به بیرون

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شناسه‌ها

نام آیوپاک 2-Methyl-3-{[(2S)-pyrrolidin-2-yl]methoxy}pyridine
شمارهٔ سی‌ای‌اس	161417-03-4^Y
پاب‌کم CID	178052
کم‌اسپایدر	155000^N
UNII	CL2002R563
CompTox Dashboard (EPA)	DTXSID20167149
داده‌های فیزیکی و شیمیایی
فرمول شیمیایی	C₁₁H₁₆N₂O
جرم مولی	۱۹۲٫۲۶۲ g·mol⁻¹
مدل سه بعدی (جی‌مول)	Interactive image
SMILES CC1=C(C=CC=N1)OC[C@@H]2CCCN2
InChI InChI=1S/C11H16N2O/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10/h3,5-6,10,13H,2,4,7-8H2,1H3/t10-/m0/s1^N Key:YRVIKLBSVVNSHF-JTQLQIEISA-N^N
^NY (این چیست؟) (صحت‌سنجی)