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Feniletanolamina N-metiltransferasa

feniletanolamina N-metiltransferasa
Estructuras disponibles
PDB

Buscar ortólogos: PDBe, RCSB

 Estructuras enzimáticas
Identificadores
Símbolos PNMT (HGNC: 9160) PENT
Identificadores
externos
Número EC 2.1.1.28
Locus Cr. 17 q21-q22
Ortólogos
Especies
Humano Ratón
Entrez
5409
UniProt
P11086 n/a
RefSeq
(ARNm)
NM_002686 n/a
PubMed (Búsqueda)
[1]


PMC (Búsqueda)
[2]

La feniletanolamina N-metiltransferasa (o PNMT del inglés: phenylethanolamine N-methyltransferase) es una enzima encontrada en la médula suprarrenal que convierte la norepinefrina (noradrenalina) en epinefrina (adrenalina).

La PNMT es positivamente influenciada por el cortisol, que es producido en la corteza suprarrenal.

El S-adenosil-L-metionina ('SAM') es requerido como cofactor.[1]

La PNMT convierte el último paso la síntesis de epinefrina

Referencias

[editar]
  1. Wong DL, Lesage A, Siddall B, Funder JW (noviembre de 1992). «Glucocorticoid regulation of phenylethanolamine N-methyltransferase in vivo». The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 6 (14): 3310-5. PMID 1426768. 

Enlaces externos

[editar]
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Feniletanolamina N-metiltransferasa
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