Tocofersolan

Names
IUPAC name α-Hydro-ω-{[4-oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl}oxy)butanoyl]oxy}poly(oxyethylene)
Other names Tocofersolan; Vitamin E PEG succinate; α-Tocopherol polyethylene glycol succinate (TPGS); Liqui-E
Identifiers
CAS Number	9002-96-4 N
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL2355578
ChemSpider	64498 Y
DrugBank	DB11635
ECHA InfoCard	100.123.651
EC Number	618-345-6
PubChem CID	9938056
UNII	O03S90U1F2 Y
CompTox Dashboard (EPA)	DTXSID90872278 DTXSID1048623, DTXSID90872278
InChI InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3 Y Key: AOBORMOPSGHCAX-UHFFFAOYSA-N Y InChI=1/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3 Key: AOBORMOPSGHCAX-UHFFFAOYAU
SMILES O=C(OCCO)CCC(=O)Oc2c(c(c1OC(CCc1c2C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)C
Properties
Chemical formula	(C2H4O)nC33H54O5
Molar mass	Variable
Pharmacology
ATC code	A11HA08 (WHO)
License data	EU EMA: by INN
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Tocofersolan

Clinical data
Trade names	Vedrop
Other names	Tocophersolan (USAN US)
AHFS/Drugs.com	UK Drug Information
Legal status
Legal status	UK: POM (Prescription only)[1] EU: Rx-only[2]
Identifiers
DrugBank	DB11635
KEGG	D06174
CompTox Dashboard (EPA)	DTXSID90872278 DTXSID1048623, DTXSID90872278
ECHA InfoCard	100.123.651

Tocofersolan (INN) or tocophersolan, also referred to as TPGS (for tocopherol polyethylene glycol succinate), is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is polyethylene glycol derivative of α-tocopherol that enables water solubility.

Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease.^[3] On 24 July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients with congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).^[4]

Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant.^[5]