TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | TIE1 | ||||||
Alt. symbols | TIE, JTK14 | ||||||
NCBI gene | 7075 | ||||||
HGNC | 11809 | ||||||
OMIM | 600222 | ||||||
RefSeq | NM_005424 | ||||||
UniProt | P35590 | ||||||
Other data | |||||||
EC number | 2.7.1.112 | ||||||
Locus | Chr. 1 p34-p33 | ||||||
|
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.[5]
Function
TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells[6] and platelets.[7] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.[8]
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.