SCG2
Identifiers
Aliases	SCG2, CHGC, SN, SgII, secretogranin II
External IDs	OMIM: 118930; MGI: 103033; HomoloGene: 2591; GeneCards: SCG2; OMA:SCG2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q36.1 Start 223,596,940 bp[1] End 223,602,361 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C4|1 40.89 cM Start 79,412,386 bp[2] End 79,417,837 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell lateral nuclear group of thalamus superior vestibular nucleus pituitary gland hypothalamus nucleus accumbens Pars compacta middle temporal gyrus anterior pituitary pars reticulata Top expressed in islet of Langerhans dorsomedial hypothalamic nucleus ventral tegmental area arcuate nucleus ventromedial nucleus mammillary body paraventricular nucleus of hypothalamus dorsal tegmental nucleus median eminence adrenal gland More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding chemoattractant activity cytokine activity Cellular component extracellular region dense core granule secretory granule extracellular space neuronal dense core vesicle endoplasmic reticulum lumen Biological process protein secretion induction of positive chemotaxis negative regulation of endothelial cell apoptotic process eosinophil chemotaxis positive chemotaxis negative regulation of extrinsic apoptotic signaling pathway intracellular signal transduction inflammatory response positive regulation of endothelial cell proliferation endothelial cell migration angiogenesis MAPK cascade negative regulation of endothelial cell proliferation post-translational protein modification regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7857 20254 Ensembl ENSG00000171951 ENSMUSG00000050711 UniProt P13521 P15321 Q03517 RefSeq (mRNA) NM_003469 NM_009129 NM_001310680 RefSeq (protein) NP_003460 NP_001297609 NP_033155 Location (UCSC) Chr 2: 223.6 – 223.6 Mb Chr 1: 79.41 – 79.42 Mb PubMed search [3] [4]
Wikidata
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SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene.^[5]

Function

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotactic effects on specific cell types, and EM66, whose function is unknown.^[6]