In the rodent, the parasubiculum is a retrohippocampal isocortical structure, and a major component of the subicular complex. It receives numerous subcortical and cortical inputs, and sends major projections to the superficial layers of the entorhinal cortex (Amaral & Witter, 1995).

The parasubicular area is a transitional zone between the presubiculum and the entorhinal area in the mouse (Paxinos-2001), the rat (Swanson, 1998) and the primate (Zilles, 1990). Defined on the basis of cytoarchitecture, it is more similar to the presubiculum than to the entorhinal area (Zilles, 1990), however electrophysiological evidence suggests a similarity with the entorhinal cortex (Funahashi and Stewart, 1997; Glasgow & Chapman, 2007). To be specific, cells in this area are modulated by local theta rhythm, and display theta-frequency membrane potential oscillations (Glasgow & Chapman, 2007; Taube, 1995). Furthermore, cells in the parasubiculum, and neighboring presubiculum, fire in relation to the animal's location in space, suggesting properties similar to place cells. It is postulated that this area may play an integral role in spatial navigation and the integration of head-directional information (Chrobak & Buzsáki, 1994; Taube, 1995).

• Brodmann area
• Subiculum

• Amaral, D. G., & Witter, M. P. (1995). "Hippocampal Formation". In G. Paxinos & C. Watson (Eds.), The rat brain in sterotaxic coordinates (3rd ed.). San Diego: Academic Press.
• Chrobak, J. J., & Buzsáki, G. (1994). "Selective activation of deep layer (V-VI) retrohippocampal cortical neurons during hippocampal sharp waves in the behaving rat". J Neurosci, 14(10), 6160–6170.
• Funahashi, M., & Stewart, M. (1997). "Presubicular and parasubicular cortical neurons of the rat: electrophysiological and morphological properties". Hippocampus, 1997;7(2):117-29.
• Glasgow, S. D., & Chapman, C. A. (2007). "Local generation of theta-frequency EEG activity in the parasubiculum". J Neurophys, doi:10.1152/jn.01306.2006.
• Taube, J. S. (1995). "Place cells recorded in the parasubiculum of freely moving rats". Hippocampus, 5(6), 569–583.
• Zilles, K., Wree, A., and Dausch, N. D. (1990) "Anatomy of the neocortex. Neurochemical organization", In: B.F. Kolb and R.C. Tees (eds.) The Cerebral Cortex of the Rat, 113–150. MIT Press, Cambridge.

• For Neuroanatomy of this area visit BrainInfo