PSME4
Identifiers
Aliases	PSME4, PA200, proteasome activator subunit 4
External IDs	OMIM: 607705; MGI: 2143994; HomoloGene: 113742; GeneCards: PSME4; OMA:PSME4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p16.2 Start 53,864,069 bp[1] End 53,970,993 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A4 Start 30,721,726 bp[2] End 30,830,361 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm glutes gastrocnemius muscle left testis biceps brachii right testis Skeletal muscle tissue of biceps brachii deltoid muscle triceps brachii muscle vastus lateralis muscle Top expressed in temporal muscle triceps brachii muscle vastus lateralis muscle sternocleidomastoid muscle digastric muscle myocardium of ventricle gastrocnemius muscle spermatid medial head of gastrocnemius muscle cardiac muscles More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding peptidase activator activity lysine-acetylated histone binding proteasome binding Cellular component cytoplasm nuclear speck proteasome complex nucleus nucleoplasm cytosol proteasome core complex spermatoproteasome complex Biological process cell differentiation regulation of cellular amino acid metabolic process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of mRNA stability positive regulation of canonical Wnt signaling pathway protein polyubiquitination stimulatory C-type lectin receptor signaling pathway tumor necrosis factor-mediated signaling pathway MAPK cascade cellular response to DNA damage stimulus positive regulation of peptidase activity multicellular organism development Fc-epsilon receptor signaling pathway NIK/NF-kappaB signaling spermatogenesis anaphase-promoting complex-dependent catabolic process T cell receptor signaling pathway negative regulation of canonical Wnt signaling pathway DNA repair proteasome-mediated ubiquitin-dependent protein catabolic process Wnt signaling pathway, planar cell polarity pathway proteasomal ubiquitin-independent protein catabolic process negative regulation of G2/M transition of mitotic cell cycle protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process transmembrane transport regulation of transcription from RNA polymerase II promoter in response to hypoxia post-translational protein modification regulation of hematopoietic stem cell differentiation interleukin-1-mediated signaling pathway regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23198 103554 Ensembl ENSG00000068878 ENSMUSG00000040850 UniProt Q14997 Q5SSW2 RefSeq (mRNA) NM_014614 NM_134013 RefSeq (protein) NP_055429 NP_598774 Location (UCSC) Chr 2: 53.86 – 53.97 Mb Chr 11: 30.72 – 30.83 Mb PubMed search [3] [4]
Wikidata
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Proteasome activator complex subunit 4 is a protein that in humans is encoded by the PSME4 gene.^[5][6][7]