OR2T11
| OR2T11 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | OR2T11, OR2T11Q, olfactory receptor family 2 subfamily T member 11 (gene/pseudogene), olfactory receptor family 2 subfamily T member 11 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | HomoloGene: 84585; GeneCards: OR2T11; OMA:OR2T11 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Olfactory receptor 2T11 is a protein that in humans is encoded by the OR2T11 gene.[3]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]
Ligands
[edit]- tert-Butylthiol (the response is enhanced by the presence of ionic copper).[4]
- Ethanethiol (the response is enhanced by the presence of ionic copper).[4]
- 2-Propenethiol (allyl mercaptan) (the response is enhanced by the presence of ionic copper).[4]
- Thietane (the response is enhanced by the presence of ionic copper).[4]
See also
[edit]References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000279301 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR2T11 olfactory receptor, family 2, subfamily T, member 11".
- ^ a b c d Li, S.; et al. (2016). "Smelling Sulfur: Copper and Silver Regulate the Response of Human Odorant Receptor OR2T11 to Low-Molecular-Weight Thiols". J. Am. Chem. Soc. 138 (40): 13281–13288. doi:10.1021/jacs.6b06983. PMID 27659093.
Further reading
[edit]- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
[edit]- OR2T11+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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| Class II (tetrapod specific receptors) |
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