NDST3
| NDST3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | NDST3, HSST3, N-deacetylase/N-sulfotransferase 3, N-deacetylase and N-sulfotransferase 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 603950; MGI: 1932544; HomoloGene: 3513; GeneCards: NDST3; OMA:NDST3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene.[5][6] It catalyses the reaction:
3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H+ + N-sulfo-α-D-glucosaminyl-[heparan sulfate](n)[7]
This is a step in the production of heparin.[7]
Clinical significance
[edit]Mutations in NDST3 have been linked to schizophrenia.[8]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000164100 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027977 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Aikawa J, Esko JD (Mar 1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J Biol Chem. 274 (5): 2690–5. doi:10.1074/jbc.274.5.2690. PMID 9915799.
- ^ "Entrez Gene: NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3".
- ^ a b "NDST3 – Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 – Homo sapiens (Human) – NDST3 gene & protein". www.uniprot.org. Retrieved 2020-01-15.
- ^ Zhang, C; Lu, W; Wang, Z; Ni, J; Zhang, J; Tang, W; Fang, Y (January 2016). "A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese". Translational Psychiatry. 6 (1): e701. doi:10.1038/tp.2015.199. ISSN 2158-3188. PMC 5068873. PMID 26731438.
Further reading
[edit]- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Aikawa J, Grobe K, Tsujimoto M, Esko JD (2001). "Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4". J. Biol. Chem. 276 (8): 5876–82. doi:10.1074/jbc.M009606200. PMID 11087757.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Boutry M, Vassarotti A, Ghislain M, et al. (1984). "Isolation of the structural genes for the alpha and beta subunits of the mitochondrial ATPase from the fission yeast Schizosaccharomyces pombe". J. Biol. Chem. 259 (5): 2840–4. doi:10.1016/S0021-9258(17)43223-6. PMID 6230352.
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