List of side effects of doxepin
The antidepressant drug doxepin has been associated with a number of different adverse effects, including the following.[1][2][3]
The incidence of these adverse effects is not totally known as the scarcity of well-designed clinical trials involving doxepin prohibits it. Side effects that are common (based on its pharmacology or the frequency of these side effects with related agents) appear with a * superscript whereas the serious side effects are in bold. Doxepin is licensed to be used in much smaller doses (viz., 3mg and 6 mg) in some countries, the side-effects profile of which may differ from this list.
- Nausea*
- Dizziness*
- Drowsiness*
- Dry mouth*
- Constipation*
- Blurred vision*
- Headache*
- Urinary hesitancy*
- Agitation*
- Hypotension (low blood pressure)
- Hypertension (high blood pressure)
- Tachycardia (high heart rate)
- Skin rash
- Facial oedema
- Photosensitisation
- Urticaria (hives)
- Pruritus (itching)
- Indigestion
- Bone fractures
- Taste disturbances
- Diarrhoea
- Anorexia (weight loss)
- Aphthous stomatitis (canker sores)
- Gynaecomastia (swelling of the breasts in men)
- Galactorrhoea (lactation that is unassociated with breast feeding or pregnancy)
- Chills
- Fatigue
- Weakness
- Flushing
- Alopecia (hair loss)
- Eosinohpilia
- Blood dyscrasias (abnormalities in the cellular composition of blood)
- Increased liver function tests
- Hyperpyrexia (high fever ≥41.5 °C or 106.7 °F)
- Seizures
- Confusion
- Malaise
- Increased appetite*
- Changes in ECG parameters (e.g. QRS & PR interval)
- Ataxia
- Hallucinations
- Paraesthesias
- Nervousness
- Numbness
- Tinnitus
- Hepatitis (liver swelling)
- Exacerbation of asthma
- Hepatic (liver) abnormalities
- Urinary retention
- Extrapyramidal symptoms
- Testicular swelling
- Hyperglycaemia (high blood sugar)
- Hypoglycaemia (low blood sugar)
- Hyponatraemia (low blood sodium)
- Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
- Closed-angle glaucoma
- Alzheimer's disease or dementia* [4]
References
[edit]- ^ "Sinepin Capsules 25mg - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Marlborough Pharmaceuticals Ltd. 22 September 2011. Retrieved 3 December 2013.
- ^ "Deptran Doxepin (as hydrochloride)" (PDF). TGA eBusiness Services. Alphapharm Pty Ltd. 6 May 2013. Retrieved 3 December 2013.
- ^ "Silenor (doxepin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 3 December 2013.
- ^ Gray, Shelly L.; Anderson, Melissa L. (January 26, 2015). "Cumulative Use of Strong Anticholinergics and Incident Dementia: A Prospective Cohort Study". JAMA Intern. Med. 175 (3): 401–7. doi:10.1001/jamainternmed.2014.7663. PMC 4358759. PMID 25621434. Retrieved January 27, 2015.
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