Govorestat
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| Other names | AT-007 |
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| Formula | C17H10F3N3O3S2 |
| Molar mass | 425.40 g·mol−1 |
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Govorestat (AT-007) is an aldose reductase inhibitor and experimental drug to treat galactosemia[1] and sorbitol dehydrogenase deficiency.[2]
After a report circulating on the internet accused the developer Applied Therapeutics of cutting corners in its studies of the drug, the FDA put a hold on it in 2020. Applied Therapeutics said that the report was a fraudulent attempt to manipulate its stock price.[3]
References
[edit]- ^ Bailey, Evan; Wang, Stella; Saltonstall, Laura; Perfetti, Riccardo; Shendelman, Shoshana (March 2022). "OP005: AT-007 significantly reduces toxic galactitol in ACTION-galactosemia kids - the 1st therapeutic interventional clinical trial in children with classic galactosemia". Genetics in Medicine. 24 (3): S336. doi:10.1016/j.gim.2022.01.556. S2CID 247603696.
- ^ "CTG Labs - NCBI". clinicaltrials.gov. Retrieved 5 November 2023.
- ^ "Bad to worse for Applied Therapeutics as FDA slaps partial clinical hold on rare drug". Retrieved 4 November 2023.
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