Gadoxetic acid
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| Trade names | Eovist |
| Other names | Gadoxetate disodium (USAN US) |
| AHFS/Drugs.com | International Drug Names |
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| Chemical and physical data | |
| Formula | C23H30GdN3O11 |
| Molar mass | 681.75 g·mol−1 |
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Gadoxetic acid is a gadolinium-based MRI contrast agent.[4] Its salt, gadoxetate disodium, is marketed as Primovist in Europe and Eovist in the United States by Bayer HealthCare Pharmaceuticals.[2][5]
Medical uses
[edit]It is used to increase the T1 signal intensity while imaging the liver lesions such as benign cysts, hemangioma, and liver cancer. It is excreted into bile by active secretion.[6]
Pharmacokinetics
[edit]In those with end-stage renal failure, the clearance rate is only 17% with terminal half-life of 12 times longer than those with normal renal function.[6]
References
[edit]- ^ "Product monograph brand safety updates". Health Canada. 7 July 2016. Retrieved 13 July 2024.
- ^ a b "Eovist- gadoxetate disodium injection, solution". DailyMed. National Library of Medicine, National Institutes of Health, U.S. Health & Human Services. Retrieved 21 April 2021.
- ^ "Active substance(s): gadoxetic acid disodium" (PDF). List of nationally authorised medicinal products. European Medicines Agency. 14 January 2021.
- ^ Koh DM, Ba-Ssalamah A, Brancatelli G, Fananapazir G, Fiel MI, Goshima S, et al. (August 2021). "Consensus report from the 9th International Forum for Liver Magnetic Resonance Imaging: applications of gadoxetic acid-enhanced imaging". European Radiology. 31 (8): 5615–5628. doi:10.1007/s00330-020-07637-4. PMC 8270799. PMID 33523304.
- ^ "Eovist - Homepage". Archived from the original on 25 April 2009. Retrieved 22 March 2009.
- ^ a b "Clinical pharmacology and biopharmaceutics review" (PDF). Center for drug evaluation and research. Archived from the original (PDF) on 12 May 2021. Retrieved 15 December 2022.
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