For faster navigation, this Iframe is preloading the Wikiwand page for Follicular B cell.

Follicular B cell

Within the immune system, Follicular B cells (FO B cells) are a type of B cell that reside in primary and secondary lymphoid follicles (containing germinal centers) of secondary and tertiary lymphoid organs, including spleen and lymph nodes. Antibody responses against proteins are believed to involve follicular B cell pathways in secondary lymphoid organs.[1]

Mature B cells from the spleen can be divided into two main populations: FO B cells, which constitute the majority, and marginal zone B-cells, lining outside the marginal sinus and bordering the red pulp. FO B cells express high levels of IgD, and CD23; lower levels of CD21 and IgM; and no CD1 or CD5, readily distinguishing this compartment from B1 B cells and marginal zone B-cells. FO B cells organize into the primary follicles of B cell zones focused around follicular dendritic cells in the white pulp of the spleen and the cortical areas of peripheral lymph nodes. Multiphoton-based live imaging of lymph nodes indicate continuous movement of FO B cells within these follicular areas at velocities of ~6 μm per min.[2] Recent studies indicate movement along the processes of FDC as a guidance system for mature resting B cells in peripheral lymph nodes.[3] Unlike their MZ counterpart, FO B cells freely recirculate, comprising >95% of the B cells in peripheral lymph nodes.

The BCR repertoire of the follicular B cell compartment also appears under positive selection pressures during final maturation in the spleen. However, diversity is substantially broader than B1 B and MZ B cell compartments. More importantly, FO B cells require CD40-CD40L dependent TFH cell help to promote effective primary immune responses and antibody isotype switching and to establish high-affinity B cell memory.[4]


  1. ^ Nutt, Stephen L.; Hodgkin, Philip D.; Tarlinton, David M.; Corcoran, Lynn M. (2015). "The generation of antibody-secreting plasma cells". Nature Reviews Immunology. 15 (3): 160–171. doi:10.1038/nri3795. PMID 25698678. S2CID 9769697.
  2. ^ Miller MJ, Wei SH, Parker I, et al. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science. 2002;296(5574):1869–1873.
  3. ^ Bajenoff M, Egen JG, Koo LY, et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity. 2006;25(6):989–1001.
  4. ^ McHeyzer-Williams LJ, McHeyzer-Williams MG. Antigen-specific memory B cell development. Annu Rev Immunol. 2005;23:487–513.
{{bottomLinkPreText}} {{bottomLinkText}}
Follicular B cell
Listen to this article

This browser is not supported by Wikiwand :(
Wikiwand requires a browser with modern capabilities in order to provide you with the best reading experience.
Please download and use one of the following browsers:

This article was just edited, click to reload
This article has been deleted on Wikipedia (Why?)

Back to homepage

Please click Add in the dialog above
Please click Allow in the top-left corner,
then click Install Now in the dialog
Please click Open in the download dialog,
then click Install
Please click the "Downloads" icon in the Safari toolbar, open the first download in the list,
then click Install

Install Wikiwand

Install on Chrome Install on Firefox
Don't forget to rate us

Tell your friends about Wikiwand!

Gmail Facebook Twitter Link

Enjoying Wikiwand?

Tell your friends and spread the love:
Share on Gmail Share on Facebook Share on Twitter Share on Buffer

Our magic isn't perfect

You can help our automatic cover photo selection by reporting an unsuitable photo.

This photo is visually disturbing This photo is not a good choice

Thank you for helping!

Your input will affect cover photo selection, along with input from other users.


Get ready for Wikiwand 2.0 🎉! the new version arrives on September 1st! Don't want to wait?