File:Ijms-24-11939-g007-550 (1).webp
No higher resolution available.
Ijms-24-11939-g007-550_(1).webp (550 × 291 pixels, file size: 23 KB, MIME type: image/webp)
 | This is a file from the Wikimedia Commons. Information from its description page there is shown below. Commons is a freely licensed media file repository. You can help. |
Summary
| Description |
English: Figure 7. Mechanism of action of onasemnogene abeparvovec. Onasemnogene abeparvovec is an scAAV9 vector-based drug [140]. After entering the host cell, the scAAV vector translocates into the nucleus, where the transgene acts as an episome (a small, stable chromosome separate from the native chromosome). The scAAV ITR increases the speed at which the double-stranded transgene is transcribed and the resulting protein is produced. The hybrid CMV enhancer and CB promoter activates the transgene to allow for continuous and sustained SMN protein expression. Abbreviations are as follows, AAV2 (adeno-associated virus serotype 2); AAV9 (AAV serotype 9); BGH Poly A (bovine growth hormone polyadenylation); CB (chicken β-actin); cDNA (complementary DNA); CMV (cytomegalovirus); ITR (inverted terminal repeat); scAAV (self-complementary AAV); SV (simian virus). |
| Date | |
| Source | https://www.mdpi.com/1422-0067/24/15/11939 |
| Author | Nishio, H.; Niba, E.T.E.; Saito, T.; Okamoto, K.; Takeshima, Y.; Awano, H. |
Licensing
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 21:33, 20 March 2024 | | 550 × 291 (23 KB) | Ozzie10aaaa | Uploaded a work by Nishio, H.; Niba, E.T.E.; Saito, T.; Okamoto, K.; Takeshima, Y.; Awano, H. from https://www.mdpi.com/1422-0067/24/15/11939 with UploadWizard |
File usage
The following pages on the English Wikipedia use this file (pages on other projects are not listed):
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.
Cover photo is available under {{::mainImage.info.license.name || 'Unknown'}} license.
Cover photo is available under {{::mainImage.info.license.name || 'Unknown'}} license.
Credit:
(see original file).
.webp){kind=link}