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Summary
| Description |
English: Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. The 12 repeats form a superhelix of helices that features a long, positively charged groove. Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove. |
| Date | |
| Source | http://www.pdb.org/pdb/explore/explore.do?structureId=2BCT |
| Author | Huber, A.H., Nelson, W.J., Weis, W.I. |
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The copyright holder of this file allows anyone to use it for any purpose, provided that the copyright holder is properly attributed. Redistribution, derivative work, commercial use, and all other use is permitted. |
Attribution:
Three-dimensional structure of the armadillo repeat region of beta-catenin. Huber, A.H., Nelson, W.J., Weis, W.I. Journal: (1997) Cell(Cambridge,Mass.) 90: 871-882
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 20:44, 8 June 2010 | | 500 × 500 (36 KB) | Eurekamarie | ((Information |Description=((en|1=Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomato |
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