Christus Santa Rosa Health System, or Christus Santa Rosa Health Care (CSRHC), is a health care organization in South Texas. Established in 1869, CSRHC is a part of Christus Health and is the only faith-based, not-for-profit health care system in San Antonio.

Centered at the South Texas Medical Center, CSRHC has hospitals located on four campuses in the San Antonio area, as well as several primary care and specialty health clinics, and an array of community outreach services. The five hospitals in operation under the CSRHC system include, Children's Hospital of San Antonio (located in Downtown San Antonio), Christus Santa Rosa Hospital-Medical Center (Medical Center), Christus Santa Rosa Hospital-Westover Hills (located on San Antonio's Westside), and Christus Santa Rosa Hospital-New Braunfels (located in New Braunfels, 30 miles northeast of Downtown San Antonio). In 2020, CSRHC acquired the hospital formerly known as Central Texas Medical Center in San Marcos, Texas, and has since rebranded the hospital as Christus Santa Rosa- San Marcos.

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Nickname: Alamo City
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Attractions	The Alamo Alamo Cenotaph Acequia Madre de Valero La Antorcha de la Amistad Basilica of the National Shrine of the Little Flower Cathedral of San Fernando Convention Center Earl Abel's Guenther House HemisFair '68 Houston Street La Villita Market Square Rivercenter River Walk St. Joseph Catholic Church Tower of the Americas Tower Life Building San Antonio Zoo and Aquarium
Museums	Artpace Blue Star Contemporary Art Museum Briscoe Western Art Museum Buckhorn Saloon & Museum Casa Navarro State Historic Site Fort Sam Houston Museum Gallista Gas Gallery Guadalupe Cultural Arts Center Guinness World Records Museum Institute of Texan Cultures McNay Art Museum Museo Alameda Museum of Aerospace Medicine O. Henry House Museum Ruby City San Antonio Academy Museum San Antonio Museum of Art Southwest School of Art Spanish Governor's Palace Edward Steves Homestead Texas Air Museum Texas Transportation Museum United States Army Medical Department Museum Witte Museum Yturri-Edmunds Historic Site See also: List of museums in Central Texas
Entertainment	Alamo City Comic Con Arneson River Theater Aztec on the River Charline McCombs Empire Theatre Fiesta Noche del Rio Fiesta San Antonio Freeman Coliseum Majestic Theatre Morgan's Wonderland Ripley's Believe It or Not! San Japan Santikos Theatres SeaWorld San Antonio Six Flags Fiesta Texas Splashtown San Antonio St. Mary's Strip Texas Folklife Festival Tobin Center for the Performing Arts (San Antonio Symphony) San Antonio Municipal Auditorium Woodlawn Theatre
Industry	Bill Miller Bar-B-Q Enterprises Christus Santa Rosa iHeartMedia Frost Bank H-E-B Jim's Restaurants Luby's M7 Aerospace NewTek NuStar Energy Rackspace San Antonio Express-News SAS Shoemakers (SAS) San Antonio Water System Security Service Federal Credit Union SWBC Taco Cabana Toyota Motor Manufacturing Texas USAA Valero Energy Visionworks of America Whataburger
Research and education	The Alamo Colleges Baptist Health System School of Health Professions Cancer Therapy & Research Center Greehey Children's Cancer Research Institute Oblate School of Theology Our Lady of the Lake University San Antonio Public Library San Antonio Municipal Archives South Texas Medical Center Texas Biomedical Research Institute Southwest Research Institute St. Mary's University Texas A&M University–San Antonio Texas Neurosciences Institute Trinity University University Health System University of the Incarnate Word University of Texas Health Science Center at San Antonio University of Texas at San Antonio
Military	San Antonio Military Medical Center Brooks City-Base Camp Bullis Fort Sam Houston Lackland Air Force Base Pershing House Randolph Air Force Base Wilford Hall Ambulatory Surgical Center
Neighborhoods	Alamo Heights Alazán-Apache Courts Brooks Dominion Downtown Inwood La Cantera Mahncke Park Monte Vista Pearl Pecan Valley Stone Oak Thompson Field
Parks	Acequia San Antonio Botanical Garden Brackenridge Park Denman Estate Park Dwight D. Eisenhower Park Friedrich Wilderness Park Government Canyon State Natural Area Phil Hardberger Park Mahncke Milam Park Miraflores Park Roosevelt Park San Antonio Japanese Tea Garden San Antonio Missions National Historical Park San Pedro Springs Park O. P. Schnabel Park Travis Park
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Transportation	San Antonio International Airport Amtrak Station VIA Metropolitan Transit
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Bexar County San Antonio–New Braunfels Metro