Carboxypeptidase B
| carboxypeptidase B1 (tissue) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CPB1 | ||||||
| NCBI gene | 1360 | ||||||
| HGNC | 2299 | ||||||
| OMIM | 114852 | ||||||
| RefSeq | NM_001871 | ||||||
| UniProt | P15086 | ||||||
| Other data | |||||||
| EC number | 3.4.17.2 | ||||||
| Locus | Chr. 3 q24 | ||||||
| |||||||
| carboxypeptidase B2 (plasma) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CPB2 | ||||||
| NCBI gene | 1361 | ||||||
| HGNC | 2300 | ||||||
| OMIM | 603101 | ||||||
| RefSeq | NM_016413 | ||||||
| UniProt | Q96IY4 | ||||||
| Other data | |||||||
| Locus | Chr. 13 q14.11 | ||||||
| |||||||
| carboxypeptidase B | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.17.2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Carboxypeptidase B (EC 3.4.17.2, protaminase, pancreatic carboxypeptidase B, tissue carboxypeptidase B, peptidyl-L-lysine [L-arginine]hydrolase) is a carboxypeptidase that preferentially cleaves off basic amino acids arginine and lysine from the C-terminus of a peptide.[1][2][3][4] This enzyme is secreted by the pancreas, and it travels to the small intestine, where it aids in protein digestion. Plasma carboxypeptidase B (carboxypeptidase B2) is responsible for converting the C5a protein into C5a des-Arg, with one less amino acid.
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