Calgranulin
Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and neutrophils.
The proteins S100A8 and S100A9 form a heterodimer called calprotectin.
Human genes
[edit]Function
[edit]Some in vitro evidence suggests that calgranulin can inhibit the precipitation of calcium oxalate in a urine-like environment at calgranulin concentrations below physiological concentrations.[1] Thus, it may also function in vivo as an inhibitor of calcium oxalate kidney stone formation. However, the role of calgranulin in the stone formation process has not been evaluated.
See also
[edit]References
[edit]- ^ Pillay S, Asplin J, Coe F (1 August 1998). "Evidence that calgranulin is produced by kidney cells and is an inhibitor of calcium oxalate crystallization". Am J Physiol. 275 (2 Pt 2): F255–61. doi:10.1152/ajprenal.1998.275.2.F255. PMID 9691016.
External links
[edit]- Calgranulin+A at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Calgranulin+B at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
| Cell membrane |
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| Intracellular signaling |
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| Extracellular chelators |
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| Calcium-binding domains | |||||||||||||||||
Major histocompatibility complex classes | |
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| MHC class I | |
| MHC class II | |
| Other | |
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