(−)-Arctigenin

Names
IUPAC name (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3- [(4-hydroxy-3-methoxyphenyl)methyl]-2-tetrahydrofuranone
Identifiers
CAS Number	7770-78-7 Y
3D model (JSmol)	Interactive image Interactive image
ChEMBL	ChEMBL435734 Y
ChemSpider	58506 Y
KEGG	C10545 Y
MeSH	arctigenin
PubChem CID	64981
UNII	U76MR9VS6M Y
CompTox Dashboard (EPA)	DTXSID60998919
InChI InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1 Y Key: NQWVSMVXKMHKTF-JKSUJKDBSA-N Y InChI=1/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1 Key: NQWVSMVXKMHKTF-JKSUJKDBBB
SMILES COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC O=C2OC[C@H](Cc1cc(OC)c(OC)cc1)[C@H]2Cc3ccc(O)c(OC)c3
Properties
Chemical formula	C21H24O6
Molar mass	372.41166
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Arctigenin is a lignan found in certain plants of the Asteraceae, including the greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral^[1] and anticancer^[2] effects in vitro. It is the aglycone of arctiin.

The use of arctigenin has been shown to be effective in a mouse model of Japanese encephalitis.^[3]

It has been found to act as an agonist of adiponectin receptor 1 (AdipoR1).^[4]