Arachidonyl trifluoromethyl ketone

Arachidonyl trifluoromethyl ketone
Names
	Preferred IUPAC name (6Z,9Z,12Z,15Z)-1,1,1-Trifluorohenicosa-6,9,12,15-teraen-2-one
	Other names Arachidonic acid trifluoromethyl ketone; Arachidonyltrifluoromethane; Arach-CF3; AACOCF3;
Identifiers
CAS Number	149301-79-1;
3D model (JSmol)	Interactive image;
ChemSpider	4444095;
PubChem CID	5280436;
UNII	00XIW1CR0F ;
CompTox Dashboard (EPA)	DTXSID901017144 ;
	InChI InChI=1S/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15- Key: PLWROONZUDKYKG-DOFZRALJSA-N;
	SMILES CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)C(F)(F)F;
Properties
Chemical formula	C21H31F3O
Molar mass	356.473 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Arachidonyl trifluoromethyl ketone (ATK) is an analog of arachidonic acid.^[1] that inhibits some isoforms of the enzyme phospholipase A2.^[2] Specifically it inhibits the 85 kDa cystolic PLA2 (cPLA2).^[2]

It has been studied as a neuroprotective agent after spinal cord injury,^[2]^[3] and in animal models of multiple sclerosis.^[4]

See also