SERPINF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2R9Y
Identifiers
Aliases	SERPINF2, A2AP, AAP, ALPHA-2-PI, API, PLI, serpin family F member 2, alpha2AP
External IDs	OMIM: 613168; MGI: 107173; HomoloGene: 719; GeneCards: SERPINF2; OMA:SERPINF2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 1,742,836 bp[1] End 1,755,265 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 75,322,558 bp[2] End 75,330,417 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver left uterine tube prostate upper lobe of left lung human kidney right ovary lactiferous gland right testis right lobe of thyroid gland myometrium Top expressed in yolk sac liver right kidney proximal tubule left lobe of liver human kidney gallbladder fetal liver hematopoietic progenitor cell abdominal wall human fetus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity protein homodimerization activity protease binding protein binding serine-type endopeptidase inhibitor activity endopeptidase inhibitor activity Cellular component blood microparticle fibrinogen complex extracellular region cell surface extracellular exosome platelet alpha granule lumen extracellular space collagen-containing extracellular matrix Biological process positive regulation of collagen biosynthetic process negative regulation of peptidase activity negative regulation of fibrinolysis negative regulation of plasminogen activation maintenance of blood vessel diameter homeostasis by renin-angiotensin blood vessel morphogenesis fibrinolysis collagen fibril organization platelet degranulation positive regulation of JNK cascade response to organic substance acute-phase response positive regulation of cell differentiation positive regulation of ERK1 and ERK2 cascade positive regulation of transforming growth factor beta production positive regulation of stress fiber assembly positive regulation of transcription by RNA polymerase II positive regulation of smooth muscle cell proliferation positive regulation of cell-cell adhesion mediated by cadherin negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5345 18816 Ensembl ENSG00000167711 ENSG00000276838 ENSMUSG00000038224 UniProt P08697 Q61247 RefSeq (mRNA) NM_000934 NM_001165920 NM_001165921 NM_008878 RefSeq (protein) NP_000925 NP_001159392 NP_001159393 NP_032904 Location (UCSC) Chr 17: 1.74 – 1.76 Mb Chr 11: 75.32 – 75.33 Mb PubMed search [3] [4]
Wikidata
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Alpha 2-antiplasmin (or α₂-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin.^[5] Plasmin is an important enzyme that participates in fibrinolysis and degradation of various other proteins. This protein is encoded by the SERPINF2 gene.^[6]

Role in disease

Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.

In liver cirrhosis, there is decreased production of alpha 2-antiplasmin, leading to decreased inactivation of plasmin and an increase in fibrinolysis. This is associated with an increase risk of bleeding in liver disease.^[7]

Interactions

Alpha 2-antiplasmin has been shown to interact with:

• Neutrophil elastase^[8][9] and
• Plasmin.^[8][10]