Doubles
2021 São Paulo Challenger de Tênis
Final
Champions	Nicolás Barrientos Alejandro Gómez
Runners-up	Rafael Matos Felipe Meligeni Alves
Score	Walkover
Events
Singles Doubles
← 2020 · São Paulo Challenger de Tênis · 2022 →

Luis David Martínez and Felipe Meligeni Alves were the defending champions^[1] but chose to defend their title with different partners. Martínez partnered Fernando Romboli but lost in the semifinals to Nicolás Barrientos and Alejandro Gómez. Meligeni Alves partnered Rafael Matos but withdrew before the final due to a positive test for COVID-19.^[2]

Barrientos and Gómez won the title by walkover after Matos and Meligeni Alves withdrew before the final.

	First round							Quarterfinals							Semifinals							Final
	1	R Matos F Meligeni Alves	6	6
		R Cid Subervi A Collarini	4	2				1	R Matos F Meligeni Alves	6	6
	WC	M Alves G Heide	3	78	[6]				O Luz I Marcondes	3	2
		O Luz I Marcondes	6	66	[10]										1	R Matos F Meligeni Alves	6	6
	3	J Cerretani L Margaroli	5	3												P Cachin M Cuevas	2	4
		P Cachin M Cuevas	7	6					P Cachin M Cuevas	77	6
	WC	D Dutra da Silva P Sakamoto	4	6	[10]			WC	D Dutra da Silva P Sakamoto	63	2
		A González T Seyboth Wild	6	3	[5]																	1	R Matos F Meligeni Alves
	PR	JP Ficovich Matías Zukas	712	3	[10]																	4	N Barrientos A Gómez	w/o
		T Lipovšek Puches JI Londero	610	6	[3]			PR	JP Ficovich M Zukas	4	63
		M Vervoort F Zeballos	77	4	[3]			4	N Barrientos A Gómez	6	77
	4	N Barrientos A Gómez	65	6	[10]										4	N Barrientos A Gómez	6	7
	Alt	L Darderi J Nikles	6	1	[10]										2	LD Martínez F Romboli	4	5
	Alt	Facundo Juárez G Villanueva	2	6	[12]			Alt	F Juárez G Villanueva	4	64
	WC	J Pereira Gabriel Roveri Sidney	1	66				2	LD Martínez F Romboli	6	77
	2	LD Martínez F Romboli	6	78

• Main draw