Doubles
2021 Los Cabos Open
Final
Champions	Hans Hach Verdugo John Isner
Runners-up	Hunter Reese Sem Verbeek
Score	5–7, 6–2, [10–4]
Events
Singles Doubles
← 2019 · Los Cabos Open · 2022 →

Romain Arneodo and Hugo Nys were the reigning champions from when the tournament was last held in 2019,^[1] but chose to play in Gstaad instead.

Hans Hach Verdugo and John Isner won the title, defeating Hunter Reese and Sem Verbeek in the final, 5–7, 6–2, [10–4].^[2]

Seeds

Draw

Key

Draw

	First round							Quarterfinals							Semifinals							Final
	1	L Bambridge K Skupski	64	77	[8]
		H Reese S Verbeek	77	64	[10]				H Reese S Verbeek	6	77
		T Huey S Johnson	77	65	[11]				T Huey S Johnson	4	63
		S Doumbia F Reboul	62	77	[9]											H Reese S Verbeek	6	77
	4	M Ebden J-P Smith	6	66	[10]										WC	M McDonald S Querrey	4	63
		H Heliövaara MÁ Reyes-Varela	3	78	[6]			4	M Ebden J-P Smith	5	3
	WC	M McDonald S Querrey	6	6				WC	M McDonald S Querrey	7	6
		N Lammons J Withrow	1	4																			H Reese S Verbeek	7	2	[4]
		A Bolt J Thompson																					H Hach Verdugo J Isner	5	6	[10]
	WC	E Escobedo L Patiño	w/o					WC	E Escobedo L Patiño	4	6	[7]
		H Hach Verdugo J Isner	77	7					H Hach Verdugo J Isner	6	2	[10]
	3	A-u-H Qureshi D Sharan	63	5												H Hach Verdugo J Isner	6	6
		S Balaji L Margaroli	6	4	[8]											T Fritz N Monroe	3	4
		T Fritz N Monroe	1	6	[10]				T Fritz N Monroe	6	4	[10]
	Alt	E Donskoy I Marchenko	62	5				2	J Erlich S González	4	6	[6]
	2	J Erlich S González	77	7