Singles
2015 Comerica Bank Challenger
Final
Champion	John Millman
Runner-up	Austin Krajicek
Score	7–5, 2–6, 6–3
Events
Singles Doubles
← 2014 · Comerica Bank Challenger · 2016 →

Marcos Baghdatis was the defending champion but chose not to compete.

John Millman won the tournament, defeating Austin Krajicek in the final, 7–5, 2–6, 6–3.

	Semifinals							Final
	1	John Millman	3	6	7
	3	Kyle Edmund	6	4	5
								1	John Millman	7	2	6
								7	Austin Krajicek	5	6	3
	4	Bjorn Fratangelo	3	62
	7	Austin Krajicek	6	77

	First round							Second round							Quarterfinals							Semifinals
	1	J Millman	6	6
	Alt	A Sarkissian	2	0				1	J Millman	6	6
		B Klein	4	4					G Andreozzi	3	2
		G Andreozzi	6	6											1	J Millman	6	6
		F Dustov	1	6	6										5	T Daniel	1	3
	Q	T Sandgren	6	2	1				F Dustov	77	5	0
	Q	Z Zhang	66	2				5	T Daniel	65	7	6
	5	T Daniel	78	6																		1	J Millman	3	6	7
	3	K Edmund	6	6																		3	K Edmund	6	4	5
	LL	T Niki	1	2				3	K Edmund	7	6
		J Zopp	4	4				Q	D Nguyen	5	3
	Q	D Nguyen	6	6											3	K Edmund	3	6	6
	WC	J Donaldson	77	6											8	Y Nishioka	6	3	3
		G Elias	62	3				WC	J Donaldson	6	3	3
	WC	M Krueger	3	6	3			8	Y Nishioka	4	6	6
	8	Y Nishioka	6	1	6

	First round							Second round							Quarterfinals							Semifinals
	6	M Ebden	77	6
		L Broady	64	3				6	M Ebden	2	77	6
	WC	T Haas	6	6				WC	T Haas	6	65	4
		A Rublev	4	3											6	M Ebden	4	2
		Y Bhambri	2	2											4	B Fratangelo	6	6
		E Ymer	6	6					E Ymer	3	4
		M Copil	6	5	2			4	B Fratangelo	6	6
	4	B Fratangelo	3	7	6																	4	B Fratangelo	3	62
	7	A Krajicek	64	6	79																	7	A Krajicek	6	77
	Alt	D Novikov	77	4	67			7	A Krajicek	6	6
	Q	M Zverev	61	7	6			Q	M Zverev	3	4
	WC	TH Fritz	77	5	3										7	A Krajicek	6	6
		G Clezar	6	1	6										2	M Jaziri	3	4
		S Devvarman	2	6	3				G Clezar	3	6	3
		K Khachanov	3	1				2	M Jaziri	6	3	6
	2	M Jaziri	6	6

• Main draw
• Qualifying draw