Singles
2010 ECM Prague Open
Final
Champion	Ágnes Szávay
Runner-up	Barbora Záhlavová-Strýcová
Score	6–2, 1–6, 6–2
Events
Singles Doubles
← 2009 · ECM Prague Open · 2011 →

The women's singles of the 2010 ECM Prague Open tournament was played on clay in Prague, Czech Republic.

Sybille Bammer was the defending champion, but chose not to participate.
Ágnes Szávay defeated Barbora Záhlavová-Strýcová in the final (6–2, 1–6, 6–2).

	Semifinals							Final
	8	Barbora Záhlavová-Strýcová	6	6
		Patty Schnyder	2	0
								8	Barbora Záhlavová-Strýcová	2	6	2
								7	Ágnes Szávay	6	1	6
		Lucie Hradecká	2	4
	7	Ágnes Szávay	6	6

	First round							Second round							Quarterfinals							Semifinals
	1	L Šafářová	6	7
		A Sevastova	4	5				1	L Šafářová
		J Larsson	6	6					J Larsson	w/o
	WC	Ka Plíšková	4	4												J Larsson	2	6	5
		A Chakvetadze	2	3											8	B Záhlavová-Strýcová	6	4	7
	Q	K Pervak	6	6				Q	K Pervak	6	4	2
		A Hlaváčková	2	4				8	B Záhlavová-Strýcová	2	6	6
	8	B Záhlavová-Strýcová	6	6																		8	B Záhlavová-Strýcová	6	6
	LL	T Paszek	64	7	4																		P Schnyder	2	0
		A Cornet	7	63	6				A Cornet	2	1
		P Schnyder	62	6	6				P Schnyder	6	6
	WC	Z Diyas	7	4	1											P Schnyder	2	6	7
		M Rybáriková	6	5	5											A Tatishvili	6	2	5
		A Tatishvili	0	7	7				A Tatishvili	6	6
		A Lapushchenkova	5	0				LL	E Hrdinová	4	3
	LL	E Hrdinová	7	6

	First round							Second round							Quarterfinals							Semifinals
	5	A Medina Garrigues	6	6
	WC	Kr Plíšková	1	3				5	A Medina Garrigues	6	6
		S Záhlavová	64	2				Q	C Castaño	4	2
	Q	C Castaño	7	6											5	A Medina Garrigues	4	5
		S Vögele	64	2												L Hradecká	6	7
		L Hradecká	7	6					L Hradecká	6	6
		M Niculescu	6	7					M Niculescu	2	1
	3	T Bacsinszky	3	5																			L Hradecká	2	4
	7	Á Szávay	6	6																		7	Á Szávay	6	6
	Q	L Ungur	4	3				7	Á Szávay	6	7
	Q	M Jugić-Salkić	4	7	2				I Benešová	1	5
		I Benešová	6	64	6										7	Á Szávay	6	6
		T Malek	4	2												P Hercog	1	4
		P Hercog	6	6					P Hercog
		T Garbin	4	6	2			2	A Dulgheru	w/o
	2	A Dulgheru	6	4	6

• Main Draw
• Qualifying Draw