The year 1629 in science and technology involved some significant events.

• In London, John Parkinson publishes Paradisi in Sole Paradisus Terrestris: a garden of all sorts of pleasant flowers which our English ayre will permit to be noursed up.^[1]

• English alchemist Arthur Dee, court physician to Michael I of Russia, compiles Fasciculus Chemicus, Chymical Collections. Expressing the Ingress, Progress, and Egress, of the Secret Hermetick Science out of the choicest and most famous authors.

• Plague breaks out in Mantua and spreads to Milan.
• In Toulouse, Niall Ó Glacáin publishes Tractatus de Peste.

• In Rome, Giovanni Branca publishes Le Machine volume nuovo, et di molto artificio da fare effetti maravigliosi tanto Spiritali quanto di Animale Operatione, arichito di bellissime figure.

• April 14 – Christiaan Huygens, Dutch mathematician and physicist (died 1695)
• Laurent Cassegrain, French priest and physicist (died 1693)
• Jan Commelijn, Dutch botanist (died 1692)
• Christophe Glaser, Swiss pharmacian (died 1672)
• Johann Glaser, Swiss anatomist (died 1675)
• Agnes Block, Dutch horticulturalist (died 1704)

• July 13 – Caspar Bartholin the Elder, Danish polymath, physician and theologian (born 1585)
• Giovanni Faber, German papal doctor and botanist (born 1574)