Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Leading Role er en award, givet af Screen Actors Guild for at ære den flotteste skuespiller-præsentation, som kvindelige hovedrolle i en film.

1994 – Jodie Foster – Nell

• Jessica Lange – Blue Sky
• Susan Sarandon – The Client
• Meryl Streep – The River Wild
• Meg Ryan – When a Man Loves a Woman

1995 – Susan Sarandon – Dead Man Walking

• Meryl Streep – The Bridges of Madison County
• Elisabeth Shue – Leaving Las Vegas
• Emma Thompson – Sense and Sensibility
• Joan Allen – Nixon

1996 – Frances McDormand – Fargo

• Kristin Scott Thomas – The English Patient
• Diane Keaton – Marvin's Room
• Brenda Blethyn – Secrets & Lies
• Gena Rowlands – Unhook the Stars

1997 – Helen Hunt – As Good as It Gets

• Judi Dench – Mrs. Brown
• Helena Bonham Carter – The Wings of the Dove
• Kate Winslet – Titanic
• Robin Wright Penn – She's So Lovely
• Pam Grier – Jackie Brown

1998 – Gwyneth Paltrow – Shakespeare in Love

• Cate Blanchett – Elizabeth
• Emily Watson – Hilary and Jackie
• Meryl Streep – One True Thing
• Jane Horrocks – Little Voice

1999: Annette Bening – American Beauty

• Hilary Swank – Boys Don't Cry
• Julianne Moore – The End of the Affair
• Meryl Streep – Music of the Heart
• Janet McTeer – Tumbleweeds

2000 – Julia Roberts – Erin Brockovich

• Juliette Binoche – Chocolat
• Joan Allen – The Contender
• Ellen Burstyn – Requiem for a Dream
• Laura Linney – You Can Count on Me

2001 – Halle Berry – Monster's Ball

• Renée Zellweger – Bridget Jones' Diary
• Sissy Spacek – In the Bedroom
• Judi Dench – Iris
• Jennifer Connelly – A Beautiful Mind

2002 – Renée Zellweger – Chicago

• Julianne Moore – Far from Heaven
• Nicole Kidman – The Hours
• Salma Hayek – Frida
• Diane Lane – Unfaithful

2003 – Charlize Theron – Monster

• Naomi Watts – 21 Grams
• Diane Keaton – Something's Gotta Give
• Evan Rachel Wood – Thirteen
• Patricia Clarkson – The Station Agent

2004 – Hilary Swank – Million Dollar Baby

• Annette Bening – Being Julia
• Kate Winslet – Eternal Sunshine of the Spotless Mind
• Imelda Staunton – Vera Drake
• Catalina Sandino Moreno – Maria, eres llena de gracia (Maria Full of Grace)

2005 – Reese Witherspoon – Walk the Line

• Felicity Huffman – Transamerica
• Charlize Theron – North Country
• Judi Dench – Mrs. Henderson Presents
• Ziyi Zhang – Memoirs of a Geisha

2006 – Helen Mirren – The Queen

• Penélope Cruz – Volver
• Meryl Streep – The Devil Wears Prada
• Kate Winslet – Little Children
• Judi Dench – Notes on a Scandal

2007 – Julie Christie – Away From Her

• Cate Blanchett – Elizabeth: The Golden Age
• Marion Cotillard – La Vie En Rose
• Angelina Jolie – A Mighty Heart
• Ellen Page – Juno

2008: – Meryl Streep – Doubt

• Anne Hathaway – Rachel Getting Married
• Angelina Jolie – Changeling
• Melissa Leo – Frozen River
• Kate Winslet – Revolutionary Road

2009 – Sandra Bullock – The Blind Side

• Helen Mirren – The Last Station som Sophia Tolstaya
• Carey Mulligan – An Education som Jenny Miller
• Gabourey Sidibe – Precious som Claireece "Precious" Jones
• Meryl Streep – Julie & Julia som Julia Child

2010 – Natalie Portman – Black Swan som Nina Sayers/Svanedronningen

• Annette Bening – The Kids Are All Right som Nic
• Nicole Kidman – Rabbit Hole som Becca
• Jennifer Lawrence – Winter's Bone som Ree Dolly
• Hilary Swank – Conviction som Betty Anne Waters

2011 – Viola Davis – Niceville som Aibileen Clark

• Glenn Close – Albert Nobbs som Albert Nobbs
• Meryl Streep – The Iron Lady som Margaret Thatcher
• Tilda Swinton – We Need to Talk About Kevin som Eva Khatchadourian
• Michelle Williams – My Week with Marilyn som Marilyn Monroe