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SEMA7A

SEMA7A
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

3NVQ

Identifikatori
AliasiSEMA7A, CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL, semaforin 7A (krvna grupa Johna Miltona Hagena)
Vanjski ID-jeviOMIM: 607961 MGI: 1306826 HomoloGene: 2678 GeneCards: SEMA7A
Lokacija gena (čovjek)
Hromosom 15 (čovjek)
Hrom.Hromosom 15 (čovjek)[1]
Hromosom 15 (čovjek)
Genomska lokacija za SEMA7A
Genomska lokacija za SEMA7A
Bend15q24.1Početak74,409,289 bp[1]
Kraj74,433,958 bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za SEMA7A
Genomska lokacija za SEMA7A
Bend9|9 BPočetak57,847,395 bp[2]
Kraj57,870,148 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
integrin binding
neuropilin binding
semaphorin receptor binding
chemorepellent activity
Ćelijska komponenta membrana
ćelijska membrana
anchored component of membrane
Vanćelijsko
external side of plasma membrane
integral component of plasma membrane
collagen-containing extracellular matrix
Biološki proces Ćelijska diferencijacija
positive regulation of protein phosphorylation
nervous system development
multicellular organism development
osteoblast differentiation
GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor
positive regulation of ERK1 and ERK2 cascade
axon extension
olfactory lobe development
integrin-mediated signaling pathway
positive regulation of axon extension
inflammatory response
neuron projection development
regulation of inflammatory response
negative chemotaxis
positive regulation of macrophage cytokine production
neural crest cell migration
positive regulation of cell migration
negative regulation of axon extension involved in axon guidance
semaphorin-plexin signaling pathway
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_003612
NM_001146029
NM_001146030

NM_011352

RefSeq (bjelančevina)

NP_001139501
NP_001139502
NP_003603

NP_035482

Lokacija (UCSC)Chr 15: 74.41 – 74.43 MbChr 9: 57.85 – 57.87 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Nekadašnji naziv John Milton Hagen sistem antigena (Milton Hagen krvna grupa), prema najnovijoj nomenklaturi je preimenovan u Semaforin 7A, GPI membransko sidro (SEMA7A), poznat i kao CD108 (Cluster of Differentiation 108), je ljudski gen.[5]

SEMA7A[5] je membranski vezani semaforin na ćelijskim površinama, vezan preko glikozilfosfatidilinozitola (GPI). SEMA7A, tj. antigen krvne grupe Milton-Hagen (JMH), je glikoprotein od 80 kD, koji se ispoljava na aktiviranim limfocitima i eritrocitima.

Genetika

[uredi | uredi izvor]

Ovaj protein ima osam varijanti u vanćelijskoj regiji: sedam leži unutarSema domene a jedan u domeni PSI.

Molekulska biologija

[uredi | uredi izvor]

Ovaj protein formira dimere.

Napomena

[uredi | uredi izvor]

Ovaj protein djeluje kao receptor malarijskog parazita Plasmodium falciparum.

Reference

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  1. ^ a b c ENSG00000288455 GRCh38: Ensembl release 89: ENSG00000138623, ENSG00000288455 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038264 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)".

Također pogledajte

[uredi | uredi izvor]
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SEMA7A
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