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Центрин

Центринът познат още като калтрактин е фосфобелтък свързващ калций, срещан е в центрозомата на еукариотите. Центринът се среща и в центриолите.[1][2]

Центринът е необходим при удвояването на центриолите.[2] Може също да играе роля при полимеризацията на микротубулите, като причинява контракции. Основното количество центрин в клетка е извън центрозомата, но неговата фунцкция все още е неизвестна.[3]

Центринът принадлежи към семейството белтъци EF-hand. Семейство белтъци, които свързват калций. Самият центрин има четири EF-hands.[4] Молекулната му маса е 20 kDa.[5]

  1. Baron, Greenwood, Bazinet, Salisbury Centrin is a component of the pericentriolar lattice[неработеща препратка]; Biology of the Cell (1992) 76, (383–388)
  2. а б Jeffrey L. Salisbury, Kelly M. Suino, Robert Busby, Margaret Springett; Centrin-2 Is Required for Centriole Duplication in Mammalian Cells; Current Biology, Volume 12, Issue 15, 6 август 2002, Pages 1287-1292; doi:10.1016/S0960-9822(02)01019-9
  3. Anne Paoletti, Mohammed Moudjou, Michel Paintrand, Jeffrey L. Salisbury and Michel Bornens; Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles; Journal of Cell Science 109, 3089-3102 (1996)
  4. Jeffrey L. Satisbury; Centrin, centrosomes, and mitotic spindle poles; Current Opinion in Cell Biology, Volume 7, Issue 1, 1995, Pages 39-45; doi:10.1016/0955-0674(95)80043-3
  5. Yaron Y. Levy, Elaine Y. Lai, Stephen P. Remillard, Matthew B. Heintzelman, Chandler Fulton;Centrin is a conserved protein that forms diverse associations with centrioles and MTOCs in Naegleria and other organisms[неработеща препратка]; Cell Motility and the Cytoskeleton, Volume 33, Issue 4, Pages 298 – 323
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Центрин
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